"It's a knockout tie. We've got a good lead from the first half of the game, but I've seen stranger things happen. We're not gonna take any chances. The players are desperate to play. We just have to have a disciplined performance, make sure we're good on the ball, dominate the ball. I wouldn't want to sit here after the game knowing that we rested too many players. The players want to get to the semi-final, final, so we're ready. The team's getting better: we're getting more and more used to each other."

United head into the second leg off the back of six successive wins in all competitions, including victory over Granada in Spain.

Tonight’s visitors ended a run of four straight defeats with a 2-1 win over Real Valladolid on Sunday.

Ole Gunnar Solskjaer switches things up following United’s 3-1 win over Tottenham last weekend. Axel Tuanzebe, Alex Telles and Nemanja Matic come in for the suspended trio of Harry Maguire, Luke Shaw and Scott McTominay. David de Gea starts in goal and Mason Greenwood replaces Marcus Rashford.

For Granada, ex-Spurs striker Roberto Soldado comes into the starting XI, while Yangel Herrera, Chelsea loanee Kenedy, Angel Montoro and Carlos Neva all get the nod.