The Israeli military has just issued a fresh update, which says its air force struck the leadership compound of the Iranian leadership.

“Numerous munitions” were dropped on Iran’s Presidential Office and the Supreme National Security Council, the IDF said in a statement on Telegram.

A military training institution and other regime infrastructure in the compound, which was used by former supreme leader Ayatollah Ali Khamenei, were also hit.

The UN human rights office has called for an investigation into the attack on a girls’ school in Iran which authorities say killed at least 165 people.

"The High Commissioner (Volker Turk) calls for a prompt, impartial and thorough investigation into the circumstances of the attack.

“The onus is on the forces that carried out the attack to investigate it," UN human rights office spokesperson Ravina Shamdasani told a Geneva press briefing, describing the incident as "horrific".

The UN avoided naming which forces it believed had carried out the strike.

Secretary of State Marco Rubio said US forces "would not deliberately target a school", after Iranian state media reported over 160 were killed on the first day of the US and Israeli attacks on Iran.

Saudi Arabia condemned an Iranian attack targeting the US embassy in Riyadh, a foreign ministry statement said.

The kingdom reserved its right to respond to the attack in order to defend its security and vital interests, including the option of responding to any aggression, the statement said.

Moscow has weighed in on the war between the US, Israel and Iran, warning that it could spur a nuclear weapon race in the Middle East.

The war may prompt not only Iran but also its Arab neighbours to seek to acquire nuclear weapons if it feels increasingly under threat by neighbouring countries, foreign minister Sergei Lavrov said.

The widening war in the Middle East increased the risk that nuclear proliferation issues could spin out of control, Lavrov said.

UN nuclear watchdog IAEA said on Tuesday there was some recent damage to entrance buildings at Iran's underground Natanz Fuel Enrichment Plant (FEP),

The agency added that it expected no radiological consequence or additional impact detected at FEP itself.

The death toll of US and Israeli strikes on Iran has hit 787 people, the UN human rights office has said, citing Iran’s Red Crescent.

The growing toll comes as Israel intensifies its attacks on Lebanon, with buildings flattened in a southern suburb of the capital of Beirut.

The US-based Human Rights Activists in Iran (HRANA), meanwhile, reports that 742 civilians have been killed, including 176 children.

The International Monetary Fund (IMF) said on Tuesday it was closely monitoring developments in the Middle East, noting disruptions to trade and economic activity, surging energy prices and increased financial market volatility.

The IMF said it was too early to assess the economic impact on the region or globally, which will depend on the extent and duration of the conflict.