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Tottenham Hotspur will be without Harry Kane and Moussa Sissoko when they take on RB Leipzig in the first leg of their round of 16 tie.
But Erik Lamela and Juan Foyth could be available for selection after missing Spurs’ comeback win over Aston Villa on Sunday.
Giovani Lo Celso returned to action at Villa Park following his recovery from a thigh injury.
Julian Nagelsmann will be without Ibrahima Konate, Willi Orban and Tyler Adams for Wednesday’s tie.
Dayot Upamecano is also suspended, meaning Chelsea loanee Ethan Ampadu may have to step up for the visitors.
Here is everything you need to know:
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Created with Sketch.
1/17 Champions League - Round of 16
Who are favourites to win this year's competition?
REUTERS
2/17 16. Lyon
French side have endured a miserable season domestically, currently languishing in 11th, and face Serie A champions Juventus without star attackers Memphis Depay and Jeff Reine-Adelaide.
REUTERS
3/17 15. Napoli
Gennaro Gattuso's side are still in transition after the departure of Carlo Ancelotti and come up against the fearsome task of facing Barcelona.
Getty Images
4/17 14. Valencia
The unlikely winners of Group H could certainly come through against Atalanta, however, they lack the depth to make a serious bid for a place in Istanbul and are currently without striker Rodrigo.
EPA
5/17 13. Atalanta
It's been an incredible story for the Bergamo-based minnows in their debut in the competition. Duvan Zapata's return provides a huge boost and they are slender favourites against Valencia, however, it would require something monumental to reach the latter stages.
EPA
6/17 12. Chelsea
Frank Lampard's side are struggling after defeat by Manchester United, with a lack of cohesion in defence and failing firepower in attack. Add the injuries to Callum Hudson-Odoi and Christian Pulisic and their chances against Bayern Munich seem extremely poor.
EPA
7/17 11. Borussia Dortmund
Lucien Favre's side are extremely dangerous, with teenagers Jadon Sancho and Erling Haaland grabbing the headlines. However, a last-16 tie against PSG provides an almighty test.
EPA
8/17 10. Tottenham Hotspur
Jose Mourinho lives for this competition and these knockout ties. Even without Harry Kane, he may just have the cunning to outwit Leipzig, but it will be a hard sell.
Getty Images
9/17 9. RB Leipzig
Come into their tie against Tottenham in tremendous form, with Timo Werner one of Europe's most prolific striker. However, their focus on a first Bundesliga title could inhibit their chances in Europe.
AP
10/17 8. Atletico Madrid
Diego Simeone's side are evolving but still have the DNA of his great, horrible sides that proved to be a tough out in seasons before. However, the task of unseating champions Liverpool will be seriously difficult.
Getty Images
11/17 7. Real Madrid
Zinedine Zidane has already won the competition three times as Real Madrid manager - but a tie against a fired-up, potentially last European saloon City leaves them as underdogs.
Getty Images
12/17 6. Juventus
Champions should be able to sweep aside Lyon in the last-16, however, there has been recent unrest under Maurizio Sarri with the club showing few improvements since Max Allegri's departure.
AFP via Getty Images
13/17 5. Bayern Munich
Have been resurgent under Hansi Flick with Robert Lewandowski in unstoppable form. They should be able to break down Chelsea's defence and enter the last-eight as serious contenders.
Bongarts/Getty Images
14/17 4. Paris Saint-Germain
Face a tough test against Dortmund but, with Neymar back - and happy, the club are better-placed than ever to finally clinch a coveted European crown.
Getty Images
15/17 3. Barcelona
Haven't quite been at their best this season but will raise their levels as the tournament progresses and will be desperate to redeem their loss at Anfield last season. Luis Suarez's absence will be sorely felt, though.
AP
16/17 2. Manchester City
Remain favourites, despite the commotion caused by the club's Uefa ban. With their Premier League hopes extinguished, Pep Guardiola's side will be more determined than ever to break their European duck.
Getty Images
17/17 1. Liverpool
Undefeated in the Premier League, with the title already wrapped up, Europe's most in-form team can dedicate all their efforts to securing back-to-back trophies.
AFP via Getty Images
1/17 Champions League - Round of 16
Who are favourites to win this year's competition?
REUTERS
2/17 16. Lyon
French side have endured a miserable season domestically, currently languishing in 11th, and face Serie A champions Juventus without star attackers Memphis Depay and Jeff Reine-Adelaide.
REUTERS
3/17 15. Napoli
Gennaro Gattuso's side are still in transition after the departure of Carlo Ancelotti and come up against the fearsome task of facing Barcelona.
Getty Images
4/17 14. Valencia
The unlikely winners of Group H could certainly come through against Atalanta, however, they lack the depth to make a serious bid for a place in Istanbul and are currently without striker Rodrigo.
EPA
5/17 13. Atalanta
It's been an incredible story for the Bergamo-based minnows in their debut in the competition. Duvan Zapata's return provides a huge boost and they are slender favourites against Valencia, however, it would require something monumental to reach the latter stages.
EPA
6/17 12. Chelsea
Frank Lampard's side are struggling after defeat by Manchester United, with a lack of cohesion in defence and failing firepower in attack. Add the injuries to Callum Hudson-Odoi and Christian Pulisic and their chances against Bayern Munich seem extremely poor.
EPA
7/17 11. Borussia Dortmund
Lucien Favre's side are extremely dangerous, with teenagers Jadon Sancho and Erling Haaland grabbing the headlines. However, a last-16 tie against PSG provides an almighty test.
EPA
8/17 10. Tottenham Hotspur
Jose Mourinho lives for this competition and these knockout ties. Even without Harry Kane, he may just have the cunning to outwit Leipzig, but it will be a hard sell.
Getty Images
9/17 9. RB Leipzig
Come into their tie against Tottenham in tremendous form, with Timo Werner one of Europe's most prolific striker. However, their focus on a first Bundesliga title could inhibit their chances in Europe.
AP
10/17 8. Atletico Madrid
Diego Simeone's side are evolving but still have the DNA of his great, horrible sides that proved to be a tough out in seasons before. However, the task of unseating champions Liverpool will be seriously difficult.
Getty Images
11/17 7. Real Madrid
Zinedine Zidane has already won the competition three times as Real Madrid manager - but a tie against a fired-up, potentially last European saloon City leaves them as underdogs.
Getty Images
12/17 6. Juventus
Champions should be able to sweep aside Lyon in the last-16, however, there has been recent unrest under Maurizio Sarri with the club showing few improvements since Max Allegri's departure.
AFP via Getty Images
13/17 5. Bayern Munich
Have been resurgent under Hansi Flick with Robert Lewandowski in unstoppable form. They should be able to break down Chelsea's defence and enter the last-eight as serious contenders.
Bongarts/Getty Images
14/17 4. Paris Saint-Germain
Face a tough test against Dortmund but, with Neymar back - and happy, the club are better-placed than ever to finally clinch a coveted European crown.
Getty Images
15/17 3. Barcelona
Haven't quite been at their best this season but will raise their levels as the tournament progresses and will be desperate to redeem their loss at Anfield last season. Luis Suarez's absence will be sorely felt, though.
AP
16/17 2. Manchester City
Remain favourites, despite the commotion caused by the club's Uefa ban. With their Premier League hopes extinguished, Pep Guardiola's side will be more determined than ever to break their European duck.
Getty Images
17/17 1. Liverpool
Undefeated in the Premier League, with the title already wrapped up, Europe's most in-form team can dedicate all their efforts to securing back-to-back trophies.
AFP via Getty Images
When is the match?
The match kicks off at 8pm at the Tottenham Hotspur Stadium.
What TV channel is it on?
The match will be shown on BT Sport 2 for UK subscribers.
Viewers can also access coverage via the BT Sport App.
Team News
Spurs will be without talisman striker Harry Kane and Moussa Sissoko, who both have long-term injuries. Erik Lamela and Juan Foyth could return after absences, but are doubts.
Leipzig have a crisis in defence with Ibrahima Konate and Willi Orban ruled out injured and Dayot Upamecano suspended. Chelsea loanee Ethan Ampadu could feature instead.
Predicted line-ups
Spurs: Lloris, Aurier, Alderweireld, Sanchez, Davies, Lo Celso, Winks, Alli, Bergwijn, Son, Lucas
Leipzig: Gulacsi, Mukiele, Klostermann, Ampadu, Halstenberg, Angelino, Laimer, Sabitzer, Olmo, Nkunku, Werner
Prediction
Spurs 2-1 RB Leipzig