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Holland and Zendaya were just 20 and 19 years old, respectively, when they first met in 2016 on the set of Spider-Man: Homecoming, during the movie's casting and initial production.
The film showed British actor Holland as Peter Parker balancing high school life with being a superhero - Spider-Man - for the first time.
It also introduced US actress Zendaya as Michelle Jones-Watson - aka MJ - his awkward but intellectual classmate.
The on-screen chemistry was clear from the start and the film received good reviews but the pair denied rumours of a romance, insisting they were just close friends while promoting the movie.
They even took to Twitter [now X] to make light of the rumours. She posted: "Wait wait ... my favourite is when it says we go on vacations together HA! I haven't been on a vacation in years! hbu @TomHolland1996 ???"
Holland responded: "Does the press tour count?"